S-Adenosyl-L-Methionine (SAMe) has several critical physiological functions and is the common thread between three key metabolic pathways. Well-recognized as a unique methyl donor for numerous biological reactions, including DNA methylation, it also links methylation to polyamine synthesis (necessary for cell survival and growth), and trans sulfuration, which is responsible for cysteine production, the rate-limiting factor in glutathione synthesis. Its unique positioning within these intersecting pathways explain its role as a regulator of redox status, cellular metabolism, proliferation and apoptosis.

Clinically it has proven beneficial for a number of conditions, most notably osteoarthritis, neurodegenerative disease, depression and liver disease. For patients with major depressive disorder, SAMe has been shown to be effective not only when compared to standard antidepressants, but also for selective serotonin reuptake inhibitor (SSRI) nonresponders. SAMe has also shown efficacy for osteoarthritis comparable to NSAIDs, including celecoxib. Quite importantly, it is likely via increases in cartilage formation, glutathione production, DNA methylation and gene expression which contribute to its efficacy, a stark contrast from pharmaceutical analgesics. Research also suggests benefit for neurodegenerative disease, and potentially for improving endothelial function.

Benefits
•Key factor in several key biological pathways, including methylation reactions, glutathione formation and glutathione-s-transferase activity
•Complexed with disulfate tosylate, a well-tolerated, stable and clinically tested form
•Enteric coating protects SAMe degradation from gastric acid, allowing for significantly improved intestinal absorption
•200 mg SAMe per tablet, allows for flexible dose titration
•Sourced from the highest quality Italian Isoactive® SAMe available on the market
•Isoactive SAMe uses a natural fermentation process that yields 40% higher active ingredients over synthetic variations